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From the perspective of healthcare reimbursement by a third-party payer, the results of our CEA and systematic review suggest that the use of GLP-1RAs versus insulin is cost-effective for T2D patients who require intensified injection therapy

21,22,45 With respect to the criteria of low physical activity, the intervention with either L-carnitine or placebo showed significant changes in the PASE score using Friedman tests, but the percent of mean changes did not show significant difference between the two groups using MannWhitney test

For more severe cases or when systemic inflammation is significant, combining both provides broader coverage

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